Melatonin Ameliorates Apoptosis of A549 Cells Exposed to Chicken House PM2.5: A Novel Insight in Poultry Production

The particulate matter 2.5 (PM2.5) from the chicken production system can cause lung injury and reduce productivity through prolonged breath as it attaches large amounts of harmful substances microbes. Melatonin has acted to regulate physiological metabolic disorders improve growth performance during poultry production. This research would investigate apoptosis caused by house PM2.5 on pulmonary epithelial cells protective action melatonin. Here, basal human adenocarcinoma (A549 cells) were subjected broiler breeding induced well alleviation was aggravated (12.5 25 μg/mL) substantially, expression Bcl-2, Bad, Bax, PERK, CHOP increased dramatically after treatment. Additionally, up-regulation cleaved caspase-9 caspase-3 endoplasmic reticulum stress (ERS)-related proteins, including ATF6 CHOP, observed due exposure. It is worth noting that melatonin could support A549 cells’ survival, in which reduced caspase-3, appeared. Concurrently, level malondialdehyde (MDA) down-regulated enhanced intracellular content total superoxide dismutase (T-SOD) catalase (CAT) treatment together with Collectively, our study underlined exerted an anti-apoptotic strengthening their antioxidant capacity.